Lathom is a locality in Lancashire, England, site of Lathom House, a seat of the Stanley family. The Siege of Lathom House in 1644, during which Charlotte de la Tremouille, Countess of Derby, defended the stronghold against Parliamentary forces, is a celebrated episode in Stanley family history with direct connections to the contemporaneous events on the Isle of Man.

The siege was fought over at a distance as well as on the ground. The royalist leaders at Chester addressed Prince Rupert about it, and the Earl of Derby had to send his own information after them because Rupert had been misinformed. The republicans, for their part, feared the Earl's standing in the county and would not trust their own soldiers if he came among them, and the committee at Manchester addressed him directly.

The house stayed a Stanley seat afterwards. The second wife of the eighth Earl died at Lathom House and was buried at Ormskirk on 16 April 1703, and the family papers of that generation are dated from it.